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Because of its anti-inflammatory effects, nattokinase has been used to help with pain from arthritis, including that of rheumatoid arthritis. Pycnogenol alleviated adverse effects in cancer patients, Pycnogenol improved working memory in older adults, Pycnogenol lowered the use of analgesic drugs in dysmenorrhea (severe menstrual pain), Pycnogenol reduced symptoms in endometriosis comparable to leuprorelin, the standard drug for this condition, Pycnogenol was found to be effective for sun-caused hyperpigmented skin, Pycnogenol reduced the inflammation in lupus patients, Pycnogenol reduced gingival bleeding and plaque formation. Cigarette smoking increases platelet aggregation. Two studies illustrate the possibilities: One was a randomized, double-blind, placebo-controlled, crossover study in which 26 asthmatic patients were given either a maximum of 200 mg a day of Pycnogenol or placebo for the first period of four weeks and then crossed over to the alternate treatment for the next four weeks. All rights reserved. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. All of our content is written by scientists and people with a strong science background. Its true. Are there any risks to taking it? Ac., CYT, 12 Benefits of Ginkgo Biloba (Plus Side Effects & Dosage), Tongkat Ali (Eurycoma longifolia): Everything You Need to Know, reduce blood sugar levels in people with diabetes, are within two weeks of a scheduled surgery, medications, herbs, and supplements that affect the blood or clotting. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox. (8). For asthma in children: 1 milligram per pound of body weight given in two divided doses. Researchers suggest this effect may be due to reduced dopamine and adrenaline levels and increased glutathione levels. Grape seed extract may be more beneficial for those who are obese. The active ingredients in pycnogenol can also be extracted from other sources, including peanut skin, grape seed, and witch hazel bark. We do not aim to diagnose, treat, cure or prevent any illness or disease. Enzogenol, a slightly different pine bark extract, improved cognitive function in a clinical trial of 42 older men after 5 weeks of supplementation [23]. Its likely that muscle recovery time improved as well due to the high antioxidants pine bark extract contains. (2017). Pycnogenol may help with other conditions as well. Certain studies used combination products, so its unknown what the contribution of Pycnogenol itself was. Blazs G, et al. The study showed that many people who participated had a drop in their systolic blood pressure after taking Pycnogenol. Posted on Thursday, August 14, 2014 The majority of this article is information obtained from the book "All About DIM" by Michael A. Zeligs, MD and A. Scott Connelly, MD. In addition to OPC, grape seed extract contains linoleic acid, flavonoids and phenolic procyanidins that help protect and strengthen capillaries, blood vessels, veins and arteries, which can then improve blood circulation. The usual recommended duration of treatment for topical application is 7 days for Pycnogenol cream and 6 weeks for Pycnogenol powder. According to researchers, it may help prevent the rise in free radicals typically seen after exercise, which could cause muscle fatigue and damage [9]. Pycnogenol French maritime pine bark extract's 4 basic properties. Pycnogenol-treated subjects experienced an improvement in all menopausal symptoms. Its quality is specified in the United States Pharmacopeia [3]. The Benefits of DIM. This study adds to a body of research showing the benefits of Pycnogenol for improving circulation and blood flow, strengthening the vascular system and managing cholesterol. Eye health. Pycnogenol may stimulate the immune system. Lets begin with asthma. Helps Treat Erectile Dysfunction. A deficiency can cause issues like anemia, stunted growth, heart problems and neural tube defects. Pycnogenol treatment led to significantly better improvement in the lung function and asthma symptoms. Instead, use plain water to wipe yourself and then dry your bottom afterward. The standard dose appears to be 100-200 mg/day. Ana spent years working with patients who suffer from various mental health issues and chronic health problems. Memorial Sloan-Kettering Cancer Center web site: "About Herbs: Pine Bark Extract. In a study of 76 people with allergic asthma, Pycnogenol (100 mg/day) added to conventional corticosteroid inhalers for 6 months helped 55% of them reduce inhaler use frequency and dosage. The goal of this study was to evaluate if Pycnogenol could prevent deep venous thrombosis (DVT) and superficial vein thrombosis (SVT) in eight-hour flights in 196 subjects at risk of these conditions. Jonathan Ritter, PharmD, PhD (Pharmacology), Small molecule antioxidants (phenolic acids, catechin, and taxifolin) are quickly absorbed and begin to act in the body within 30 min, The remaining more complex antioxidants (long chains of procyanidins) reach the gut, where your, The microbiome-produced active compounds appear in blood 6 h later and remain for at least 14 h, Pycnogenol is standardized to contain 70 5% procyanidins, which should be on the label, Pycnogenol standardization doesnt determine other major active compounds, which can vary. In theory, pine bark may lower blood pressure and blood sugar level, and these effects have also been reported in some RCTs. Pycnogenol treatment resulted in more normal-looking sperm. In a small/preliminary study of kids with asthma, pycnogenol helped improve symptoms. During week, five without, treatment, reduction of cramps was maintained in all three groups. It can then lead to heart problems like stroke or heart attack. In long-haul flights, Pycnogenol could be an effective prevention for blood clots. Research indicates that Pycnogenol provides an increase in survival performance of train athletes. In a clinical trial of 40 men with erectile dysfunction, 92.5% of the men on this combination regained normal erections after 3 months. For mild high blood pressure: 200 milligrams daily. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. The effects of the pine bark extract showed significant lower levels of blood glucose and improved endothelial function when compared to placebo, concluding that supplementation of Pycnogenol for . Pycnogenol significantly reduced the swelling as well as the feeling of heaviness. PQQ (pyrroloquinoline quinone), also called methoxatin, is a vitamin-like compound that exists naturally in soil and a variety of foods, including spinach, kiwi, soybeans, and human breastmilk . Pycnogenol lotions applied postirradiation reduced this immunosuppression to 22% (0.05% Pycnogenol) and 13% (0.1% Pycnogenol). (2004). After stopping Pycnogenol for one month, symptoms Disease of the retina in the eye. Pycnogenol is a compound of natural chemicals. Pycnogenol (125 mg/day) had the same effects in another study of 48 people with diabetes and high blood pressure. Pycnogenol seems well-tolerated for use in adults for up to 6 months. There havent been any studies looking at long-term liver damage. Some research suggests that procyanidins may have antioxidant and anti-inflammatory activity. Pycnogenol is not approved by the FDA for medical use. Improve cardiovascular health. It also provides powerful antioxidant protection and helps inhibit inflammatory factors to support. Eighty-six patients were treated either with Pycnogenol at 150 mg or 300 mg daily or the drugs diosmin and hesperidin (Daflon)at 1,000 mg daily for two months. Pycnogenol (100 mg/day) supplementation may decrease symptoms of the common cold and speed up recovery, according to a clinical trial of 146 people. One study suggests that Pycnogenol has no effect when given just 3 weeks beforehand, as it possibly requires a lag time to stabilize the immune response [17]. 5. Study participants took pine bark extract as a supplement, and it was found to be most effective in women who started out with dry skin. Interesting activities, new dishes in restaurants, specialty ingredients, explanations of some netizens questions, etc.Hu Xuan is even helping Fatty s company s tourism manager, managing with Vice President Du Meixin, such as arranging guests reasonably.By the way.Dad, I want to tell you something.I plan to invest in the hotels and entertainment centers in the . We don't yet know what the best dose to use is, but studies have used two 50 mg Pycnogenol capsules per day. Additionally, athletes have endured less cramping and muscle pain when using the extract. Proper nutrition is essential for ADHD treatment. Thirty patients were treated with 150 mg of Pycnogenol a day and the other 10 patients with placebo for a period of two months. 7. (2006). For diseases of the retina, including those related to diabetes: 50 milligrams three times daily. A 10 week clinical trial with 30 children shows that Pycnogenol may improve symptoms of Crohns disease. ( 4) Thus, this powerful extract works as a natural ear infection remedy while improving balance and preventing hearing loss. (5). However, some of these other pine bark extracts can have different active compounds, which may affect their biological activity. Pine bark extract has been studied with regard to its ability to help diabetic patients. However, it's always a good idea to start with a low dose so you can monitor how your body responds. Another one of its exemplary effects is helping manage blood pressure levels. Make sure to seek out the advice of your physician prior to using pine bark extract or the branded name, Pycnogenol. Pycnogenol is a substance taken from the pine bark of trees found in the southwest region of France. It can also be used for local application on the skin without the risk of side effects. Pycnogenol reduced foot swelling in 79% of the patients, versus one percent in the placebo group. Consider pine bark extract through a conversation with your physician or a functional medicine doctor. Researchers suggest it may boost sustained attention, memory, executive functions, mood, and reduce oxidative stress [19]. Pycnogenol in metabolic syndrome and related disorders [Abstract]. 3. It also slightly decreased blood pressure and increased testosterone [67]. While much of this is positive, it will be a while before doctors routinely recommend this dietary supplement for these conditions. Taking pine bark extract also increases the blood . Learn about all the potential benefits of Pycnogenol and find out which ones are most supported by science. Can Pycnogenol help? Pycnogenol has several benefits to your health and beauty. You can gradually increase how much you take once you get a better idea of how your body reacts to it. In those treated with Pycnogenol, the edema score was increased by 17.9% versus an increase of 58.3% in the control group. The authors attributed the negative results to the short duration of treatment and the low dosages of drug or Pycnogenol. Pycnogenol also treatment improved blood vessel function. Helps Increase Athletic Performance. In 1535, a French explorer by the name of Jacques Cartier found himself ice-bound on the St. Lawrence River. There havent been enough studies yet to change practice protocols for treating children. All Pycnogenol-treated patients responded favorably in contrast to placebo treatment. In one study, 10 patients were treated with placebo and 30 patients were treated with Pycnogenol (100 mg twice or three times daily for two months). In this study, 155 peri-menopausal women were enrolled in a double-blind, placebo-controlled study. Can you get pycnogenol naturally from foods? It can also be found as creams, lotions or ointments, typically containing 0.5 percent to 2 percent pine bark extract. This can cause pain, especially in areas of the body that are used repeatedly, like your hands, fingers, and knees. A randomized clinical trial of 30 people found that Pycnogenol (150 mg/day) may help heal vein ulcers from surgery and reduce swelling after 3 months of treatment [25]. Beta 1-3D Glucan is recognized by cells in the immune system, and can modify your immune system responses. Mental function. The U.S. Food and Drug Administration (FDA) does regulate dietary supplements; however, it treats them like foods rather than medications. In combination with Mirtoselect, Pycnogenol may improve blood flow to the eye and reduce eye blood pressure as shown in a trial of 38 people [81]. But what makes this miracle ingredient so amazing? According to a large analysis, Pycnogenol may reduce osteoarthritis symptoms and pain short-term [45, 46]. In a good-quality study, 24 adults aged 24 to 53 years old with attention deficit hyperactivity disorder (ADHD) were given Pycnogenol, placebo, or the standard drug for three weeks. Fundukian, L.J. The 2012 study on the anti-aging benefits of Pycnogenol is commonly-cited by anti-aging supplement manufacturers. Pycnogenol seems to help with asthma and allergies. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. Although the preliminary studies show many health benefits with the use of Pycnogenol, future larger and better studies are needed. In the study, many of the participants on Pycnogenol reduced their dosage of high-blood-pressure medication (nifedipine) [37]. Pine bark extract can help reduce muscle soreness and may help improve conditions relating to poor circulation, high blood pressure, osteoarthritis, diabetes, ADHD, female reproductive issues, skin, erectile dysfunction, eye disease and sports stamina. 3. Symptoms include swelling in ankles and legs, discolored skin and, if the skin is broken, the development of leg ulcers. One way to add some extra flavor and nutrients to your day is by adding prune juice to your diet. She is a strong advocate of integrating scientific knowledge and holistic medicine. In contrast, almost 20% of the participants on inhalers alone had to increase their dosage. - Please read carefully and implement principles included in the Health Recovery Plan. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. Taking pycnogenol daily for 2 months seems to slow or prevent further worsening of retinal disease caused by diabetes, atherosclerosis, or other diseases. Note that the numbers in parentheses (1, 2, etc.) You may want to start slow, taking smaller amounts, to ensure that your body works well with the OPCs found in pine bark extract. Healthline Media does not provide medical advice, diagnosis, or treatment. Researchers suggest that it may have stronger benefits than elastic compression stockings. Pine bark extract can make a great addition to your nutritional arsenal for its potent antioxidant support, as well as its added support for blood flow, blood sugar, inflammation, immunity, brain function and skin support. A trial of 53 students found that pycnogenol may improve cognitive function, memory, attention, mood, and mental performance after 8 weeks [20]. A new peer-reviewed study, published in the Bratislava Medical Journal, shows that daily supplementation with the natural antioxidant, Pycnogenol, a French maritime pine bark extract, can improve the symptoms of ED.. In a double-blind, placebo-controlled, randomized, crossover study, 50 patients with erectile dysfunction (ED) were treated with either L-arginine plus Pycnogenol or placebo for a month. Our team aims to be not only thorough with its research, but also objective and unbiased. But what are its health benefits? It is standardized to contain 65-75% procyanidins, a class of polyphenols and flavonoids like those found in blueberries, wine, grape skin, citrus, and cocoa. Regardless, a natural option is available and far worth the wait. Possess Anti-Inflammatory Action. Sign Up for the Latest Health News and Tips, Home Food and Nutrition Pycnogenol (French Maritime Pine Bark Extract): 12 Benefits According to Studies. A 2017 review reported on the many benefits of using pine bark extract to reduce the effects of aging on skin. Note that the numbers in parentheses (1, 2, etc.) Pycnogenol has given indications that it might be able to benefit heart and artery health, to include reducing high blood pressure. In one study, people with high blood pressure were examined to see how the supplement impacted their blood pressure. In another trial, 30 people with type 2 diabetes received a range of pycnogenol doses. This condition can be temporary or permanent however, some studies have indicated that pine bark extract may help alleviate these symptoms due to its high presence of antioxidants. Although these may still be high quality, the active compounds are more likely to vary. Importantly, all studies found that Pycnogenol has to be taken at least 5 weeks before the allergy season in order to see potential benefits, with the best results in those who take it 7-8 weeks ahead. Berberine is a compound extracted from several plants. In 1534, a French ship led by the famous explorer Jacques Cartier became stranded in ice near Quebec, Canada. Masquelier was easily able to create a pine bark extract from materials that were otherwise known as waste. Note that each number in parentheses [1, 2, 3, etc.] A study of 68 people found that Pycnogenol, started 2 days prior to flying, may reduce the duration of jet lag symptoms [83]. Pycnogenol is a patented extract of the French maritime pine bark (Pinus pinaster). While it may seem intimidating at first, counting macros is a common Erythritol is now one of the most popular natural zero-calorie sweeteners available. Here are some basic guidelines as reported by WebMD: While most studies do not indicate major side effects, pine bark extract may cause irritability and fatigue, and could interact with other drugs. Potential benefits of folic acid include a reduced risk of cancer, improved cognitive function, stronger bones, enhanced heart health, better pregnancy outcomes and reduced symptoms of restless legs syndrome. A systematic review of 14 studies found that Pycnogenol gum or mouthwashes may reduce dental plaque, but the quality of evidence is low [58, 59]. (3), Ototoxicity is ear poisoning and can occur when exposed to certain drugs or chemicals, such as cisplatin, that damage the inner ear or the vestibulocochlear nerve. A study of 66 healthy adults found that Pycnogenol may reduce the number of leg cramps experienced [11]. It is found primarily in southwestern France and is used to help people with asthma, allergies, hay fever, and other health conditions.. In the following sections, well discuss the common forms and dosages of Pycnogenol that are commercially available. Some studies have suggested it may modestly improve blood pressure, cholesterol, and C-reactive protein. If you knew you could resolve your erectile dysfunction and, therefore, naturally remedy impotence issues, wouldnt you? ", Mayo Clinic: High blood pressure (hypertension)., Panminerva Medica: "Pycnogenol improvements in asthma management. As I mentioned, pine bark extract is superior when it comes to antioxidants. Speak with your doctor before supplementing. It also may help those on blood pressure medications to reduce their dose [32]. Arginine is a non-essential amino acid because most humans can make it in their bodies. They were given Pycnogenolfor a period of 10 days. New studies show Pycnogenol can prevent or reverse the oxidative damage that produces blood vessel disease 4, metabolic syndrome 20, diabetes 20,24, and neurodegenerative disorders 23,24. Some people seek to manage ADHD symptoms through an ADHD diet. Studies have found that when taken along with an inhaler, Pycnogenol can reduce leukotrienes, helping to relieve lung inflammation and limit frequency of inhaler use., Many people develop osteoarthritis as they age. The top benefits of nattokinase include the following: Regulate blood pressure. This condition is due to the pooling of blood in the veins of the lower legs. The review found evidence that pine bark extract may: Similar to its neuroprotective benefits, the metabolic benefits of pine bark extract seem to be related to its antioxidant and anti-inflammatory properties. We all know the power of antioxidants to improve health and thehigh-antioxidant foodswe should eat regularly. ", Panminerva Medica: "Supplementation with Pycnogenol improves signs and symptoms of menopausal transition.". Our website services, content, and products are for informational purposes only. Pycnogenol French maritime pine bark extract acts as a potent blend of antioxidants, it is a natural anti-inflammatory, stimulates generation of collagen and hyaluronic acid and help with natural dilation of blood vessels by supporting production of nitric oxide. Align your health hacks with your genes for optimal health & cognitive function. Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. The crew fell extremely ill from scurvy, an extreme lack of vitamin C. Cartiers crew crossed paths with a Quebec Indian who encouraged them to drink a tea made from pine bark and needles. The Best Supplements for Healthy Digestion, How to Get the Protective Power of Vitamin K. In 7 volunteers, Pycnogenol (300 mg) for 5 days may reduce the activity of a crucial inflammatory gene (NF-B) [53]. The combination of Panax ginseng and vitamin E also appears to have an effect. DOI: Luzzi R, et al. There is limited evidence that it could be used in treating Attention Deficit Hyperactivity Disorder (ADHD). Pycnogenol-treated patients reported significant improvement with knee pain, as compared to the placebo group. The positive improvements in symptoms were greater among those taking Pycnogenol. DIM and other plant indoles are found in . Thus, this powerful extract works as a natural ear infection remedy while improving balance and preventing hearing loss. For most people, pine bark extract doesn't cause any side effects. They were treated with 200 mg of Pycnogenol daily or with placebo. You should also avoid using pine bark extract without talking to your doctor first if you: You should also do additional research or talk to your doctor before taking pine bark extract if you also take: While pine bark extract is a natural supplement, it can have powerful effects on your health, both positive and negative. Add to Cart. Helps maintain high vitamin C and E blood levels for their antioxidant effects. Dr. Eric L. Zielinski is a sought-after natural . There is currently insufficient evidence to determine what a safe and effective dose of lysine is for specific conditions. No side effects were noted, unlike its synthetic counterpart. While the aspirin reduced the risk for cardiovascular disease and colorectal cancer, among other cancers, the risk of gastrointestinal bleeding outweighed those benefits, creating more risks to the body. In another good study, 48 patients with diabetes and high blood pressure on ACE inhibitors were randomized to receive either Pycnogenol 125 mg daily or placebo for 12 weeks. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Millions are hospitalized each year for . Pycnogenol supplementation reduced skin redness from UV rays in a trial of 21 people over 8 weeks. The remaining compounds are phenolic acids, which may also have antioxidant activity [1, 2]. For improving exercise capacity in athletes: 200 milligrams daily. 2005-2023 Healthline Media a Red Ventures Company. Tierra Mia Coffee Menu Calories,
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